Endocrine Abstracts

Introduction: Sheehan syndrome (SS) is a hemorrhagic necrosis of the pituitary gland responsible of anterior pituitary insufficiency. It occurs in a context of cerebral hypo flow due to a rapid blood pressure drop and/or acute hemorrhagia. We report a case of SS revealed by acute corticotropic insufficiency.Case report: A sunday morning 34 years-old woman consulted the emergency department for of a fatigue and diarrhea. She reported a 7 kg weight-loss in...

Primary hyperparathyroidism is a frequent endocrine disorder but intrathyroidal parathyroid adenoma is extremely rare. Combining cervical ultrasound and MIBI scintigraphy allows localizing most parathyroid adenomas. Because intrathyroidal parathyroid adenomas mimic thyroid nodules the diagnosis can be challenging, requiring eventually the realization of a fine-needle cyto-puncture. We report here a case of an intrathyroidal parathyroid adenoma diagnosed via a combination of ce...

Oncocytic adrenocortical neoplasm (OAN) represents a rare variant of adrenocortical carcinoma (ACC) with less than 150 cases reported in the literature. OANs account for 1.8% of adrenal masses, predominantly in adults and usually presenting as large tumors featuring hormonal secretion in 20% of cases. Accurate histological characterization of OANs is crucial as this subtype is believed to be more indolent in clinical behavior. There are 3 categories of OANs: pure oncocytic, mi...

Cushing disease is a rare endocrine disorder characterised by excess production of adrenocorticotropic hormone (ACTH) from a pituitary adenoma causing an excessive stimulation of the adrenal glands resulting in hypercortisolism. Most common clinical presentation includes a combination of signs like central obesity, facial plethora,ecchymosis, purple skin striae, hirsutism, acne, muscle weakness and atrophy. Hypertension, glucose intolerance and diabetes, hypokalaemia and osteo...

Primary hyperparathyroidism is the third most common endocrine disorder, caused, in the majority of cases, by a single parathyroid adenoma and rarely by multigland adenoma or parathyroid carcinoma. Giant parathyroid adenomas, defined as larger than 3 g, represent an uncommon cause of primary hyperparathyroidism, with only a few cases described in the literature. We present the case of a 47 years old female who presented with a significant, unpainful, left cervical mass associa...

Pheochromocytoma is a rare tumor of the adrenal medulla, responsible for excessive secretion of catecholamines. Symptoms include the classic triad: headache, palpitations and sweating, usually accompanied by hypertension. We report the case of a pheochromocytoma diagnosed following an episode of testicular necrosis. A 72-year-old patient with history of psoriasis and prostate resection underwent emergency surgery for increased testicular pain suspicious of testicular tumor. Pa...

Oncocytic adrenocortical neoplasms (OAN) were first described by Kakimoto et al. in 1986. Since then, only 160 cases have been reported in the literature. There are 3 categories of OANs: pure oncocytic, mixed oncocytic and ordinary adrenocortical with focal oncocytic changes. Although the majority of OANs are considered benign tumors, certain OANs may present similar characteristics to adrenocortical carcinoma, correct histological caractherisation is therefore crucia...